腺管構造の混在した食道類基底扁平上皮癌の1例

一坂 俊介; 菊永 裕行; 天田 塩; 皆川 卓也; 櫻川 忠之; 森 克昭; 石川 啓一; 堂脇 昌一; 藤田 晃司; 金森 英彬; 伊藤 貴; 林 篤; 辻川 華子; 三上 修治; 熊井 浩一郎

doi:10.11641/pde.82.1_104

A case of carcinoma of the esophagus with mixed basaloid squamous and glandular differentiation

Shunsuke Ichisaka, Hiroyuki Kikunaga, En Amada, Takuya Minagawa, Tadayuki Sakuragawa, Katsuaki Mori, Keiichi Ishikawa, Shoichi Dowaki, Koji Fujita, Hideaki Kanamori, Takashi Itoh, Atsushi Hayashi, Hanako Tujikawa, Shuji Mikami, Kohichiro Kumai

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Shunsuke Ichisaka
Department of Surgery, Hino Municipal Hospital
Hiroyuki Kikunaga
Department of Surgery, Hino Municipal Hospital
En Amada
Department of Surgery, Hino Municipal Hospital
Takuya Minagawa
Department of Surgery, Hino Municipal Hospital
Tadayuki Sakuragawa
Department of Surgery, Hino Municipal Hospital
Katsuaki Mori
Department of Surgery, Hino Municipal Hospital
Keiichi Ishikawa
Department of Surgery, Hino Municipal Hospital
Shoichi Dowaki
Department of Surgery, Hino Municipal Hospital
Koji Fujita
Department of Surgery, Hino Municipal Hospital
Hideaki Kanamori
Department of Internal medicine, Hino Municipal Hospital
Takashi Itoh
Department of Internal medicine, Hino Municipal Hospital
Atsushi Hayashi
Department of Internal medicine, Hino Municipal Hospital
Hanako Tujikawa
Department of Pathology, School of Medicine, Keio University
Shuji Mikami
Division of Surgical Pathology, Keio University Hospital
Kohichiro Kumai
Department of Surgery, Hino Municipal Hospital

Keywords: basaloid squamous carcinoma of the esophagus, glandular differentiation

JOURNAL FREE ACCESS

2013 Volume 82 Issue 1 Pages 104-105

DOI https://njjn-jsjc-gov-cn-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.11641/pde.82.1_104

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Abstract

During health assessment of an 81-year-old male, endoscopy detected a depressed lesion with ulceration in the lower esophagus. Histological analysis of biopsies diagnosed squamous cell carcinoma, but the findings were atypical and─due to the histological appearance of glandular structures─there was suspicion of basaloid squamous carcinoma (BSC). Lower esophagectomy was performed, and histology of resected tissue demonstrated BSC mixed of trabecular components and glandular structures, with squamous cell carcinoma in-situ at the border of the ulcerative lesion. The final histological diagnosis was：carcinoma with mixed basaloid squamous and glandular differentiation, pT1b(SM3), INFc, ly0, v1, N0, M0. BSC of the esophagus is a rare but distinct variant of esophageal carcinoma, and the incidence of BSC has been reported as 1.3% of total esophageal malignant tumors. Histologically, esophageal BSC displays a variety of features, but few cases show glandular structures. We describe an unusual case report of esophageal BSC with glandular differentiation.

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