LC/Tribrid Orbitrapによる強壮系健康食品中のPhosphodiesterase-5阻害薬および構造類似体の分析

坂本 美穂; 蓑輪 佳子; 岸本 清子; 中嶋 順一; 鈴木 仁; 守安 貴子; 深谷 晴彦; 斉藤 貢一

doi:10.3358/shokueishi.60.96

Original paper

LC/Tribrid Orbitrap Analysis of Phosphodiesterase-5 Inhibitors and Their Analogs as Adulterants in Dietary Supplements

Miho Sakamoto , Keiko Minowa, Kiyoko Kishimoto, Jun’ichi Nakajima, Jin Suzuki, Takako Moriyasu, Haruhiko Fukaya, Koichi Saito

Author information

Keywords: sildenafil, tadalafil, vardenafil, dietary supplement, LC, MS

JOURNAL FREE ACCESS
Supplementary material

2019 Volume 60 Issue 4 Pages 96-107

DOI https://njjn-jsjc-gov-cn-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.3358/shokueishi.60.96

Details

Abstract

LC/Tribrid Orbitrap was developed to determine phosphodiesterase-5 (PDE-5) inhibitors and their analogs as adulterants in dietary supplements. High-resolution MS/MS and MS³ spectra of PDE-5 inhibitors and their analogs were obtained by LC/Tribrid Orbitrap using both higher-energy collisional dissociation and collision-induced dissociation. We investigated dietary supplements that claim to enhance men’s sexual performance, and detected PDE-5 inhibitors and their analogs. We also estimated the structures of the PDE-5 inhibitor analogs and the impurities of PDE-5 inhibitors and their analogs in the dietary supplements.

Corresponding author

Register with J-STAGE for free!