Abstract
A 60 years old woman was administered prednisolone (PSL) continuously because of autoimmune hepatitis (AIH) for 6 years. She was admitted to our hospital with purpuric rash on her extremities and hematochezia. We found erosion and multiple ulceration on terminal ileum by endoscopic examination of lower gastrointestinal tract and on the second portion of duodenum by endoscopic examination of upper gastrointestinal tract. We diagnosed anaphylactoid purpura from the biopsy of purpura and remarkable decline of factor XIII. She transiently got better without more administration (PSL was administrated as before) , but had recurrence of the disease. We administrated factor XIII concentrate to her for 3 days. She immediately got better after administration of factor XIII concentrate. In this case PSL may be resistant to the anaphylactoid purpura, because she was taken the disease during administration of PSL. And factor XIII concentrate may be effective to anaphylactoid purpura in adult.
