Cytogenetic Biodosimetry in Radiation Emergency Medicine: 2. Biosafety and Chemical Safety in Biodosimetry Laboratory

Kosuke Kasai; Yu Abe; Valerie Goh Swee Ting; Mai Tran Thanh; Yohei Fujishima; Ryo Nakayama; Kai Takebayashi; Akifumi Nakata; Kentaro Ariyoshi; Hiroyuki Hanada; Mitsuaki A. Yoshida; Katsuhiro Ito; Tomisato Miura

doi:10.51083/radiatenvironmed.11.1_34

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Cytogenetic Biodosimetry in Radiation Emergency Medicine: 2. Biosafety and Chemical Safety in Biodosimetry Laboratory

Kosuke Kasai, Yu Abe, Valerie Goh Swee Ting, Mai Tran Thanh, Yohei Fujishima, Ryo Nakayama, Kai Takebayashi, Akifumi Nakata, Kentaro Ariyoshi, Hiroyuki Hanada, Mitsuaki A. Yoshida, Katsuhiro Ito, Tomisato Miura

Author information

Kosuke Kasai
Department of Bioscience and Laboratory Medicine, Hirosaki University Graduate School of Health Sciences, 66-1 Hon-cho, Hirosaki, Aomori 036-8564, Japan
Yu Abe
Department of Radiation Biology and Protection, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Nagasaki 852-8523, Japan
Valerie Goh Swee Ting
Department of Radiobiology, Singapore Nuclear Research and Safety Initiative, National University of Singapoore, 1 Create Way, Singapore 138602, Singapore
Mai Tran Thanh
Biodosimetry Group, Centre of Radiation Technology and Biotechnology, Dalat Nuclear Research Institute, 1 Nguyen Tu Luc, Ward 8, Dalat City, Lamdong Province, Vietnam
Yohei Fujishima
Department of Risk Analysis and Biodosimetry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki, Aomori 036-8564, Japan
Ryo Nakayama
Department of Bioscience and Laboratory Medicine, Hirosaki University Graduate School of Health Sciences, 66-1 Hon-cho, Hirosaki, Aomori 036-8564, Japan
Department of Risk Analysis and Biodosimetry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki, Aomori 036-8564, Japan
Kai Takebayashi
Department of Bioscience and Laboratory Medicine, Hirosaki University Graduate School of Health Sciences, 66-1 Hon-cho, Hirosaki, Aomori 036-8564, Japan
Department of Risk Analysis and Biodosimetry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki, Aomori 036-8564, Japan
Akifumi Nakata
Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 15-4-1, Maeda 7-jo, Teine-ku, Sapporo, Hokkaido 006-8585, Japan
Kentaro Ariyoshi
Center for Integrated Science and Humanities, Fukushima Medical University, 1 Hikariga-oka, Fukushima City, Fukushima, 960-1295, Japan
Hiroyuki Hanada
Advanced Emergency and Critical Care Center, Hirosaki University Hospital, Hirosaki University, 53 Hon-cho, Hirosaki, Aomori 036-8563, Japan
Mitsuaki A. Yoshida
Department of Risk Analysis and Biodosimetry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki, Aomori 036-8564, Japan
Institute of Chromosome Life Science, 11-5-409, Fukuokachuo 2-Chome, Fujimino-shi, Saitama 356-0031, Japan
Katsuhiro Ito
Advanced Emergency and Critical Care Center, Hirosaki University Hospital, Hirosaki University, 53 Hon-cho, Hirosaki, Aomori 036-8563, Japan
Tomisato Miura
Department of Risk Analysis and Biodosimetry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki, Aomori 036-8564, Japan

Keywords: cytogenetic biodosimetry, laboratory management, biosafety, chemical safety, emergency response

JOURNAL FREE ACCESS

2022 Volume 11 Issue 1 Pages 34-39

DOI https://njjn-jsjc-gov-cn-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.51083/radiatenvironmed.11.1_34

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Abstract

In a biodosimetry laboratory, blood collected from exposed patients is cultured and the exposure dose is estimated based on the frequency of chromosome aberrations. Blood is defined as an infectious specimen because it may contain hepatitis virus and human immunodeficiency virus (HIV) and must be handled in a biosafety level (BSL) 2 facility. Due to the recent coronavirus pandemic with SARS-CoV-2, further strengthening of infection control measures is required. This article outlines the requirements for setting up a BSL2 laboratory, personal protective equipment for infection control, treatment of infectious biological waste and emergency response measures. Furthermore, it is essential to safely manage hazardous chemicals used in biodosimetry. Biodosimetry laboratories should conduct risk assessments of blood handling and chemical use and consider risk mitigation measures. In addition, laboratory personnel must educate workers on infection control and chemical safety.

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