Dental Journal of Iwate Medical University
Online ISSN : 2424-1822
Print ISSN : 0385-1311
ISSN-L : 0385-1311
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Volume 37, Issue 1
Displaying 1-14 of 14 articles from this issue
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  • Relationship between ACP classification and the opening position, direction of the mental foramen and anterior loop in edentulous patients
    Ken Sasaki, Junichi Furuya
    Article type: Article
    2012 Volume 37 Issue 1 Pages 1-13
    Published: May 11, 2012
    Released on J-STAGE: March 06, 2017
    DOIhttps://njjn-jsjc-gov-cn-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.20663/iwateshigakukaishi.37.1_1
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    Imaging examinations of mental foramen is important in prosthetic treatment for edentulous patients such as implant over denture and compression of the mental nerve by complete dentures. However, imaging examinations of mental foramen have been using evaluated a two-dimensional analyses on panoramic radiographs, and the relationships with ridge resorption has not been clarified. The purpose of this study was to clarify the relationship between ACP classification and the opening direction and position of the mental foramen in edentulous patients using cone-beam CT. Subjects were divided into two groups: 17 edentulous patients classified into four categories based on the degree of ridge resorption; and 10 healthy dentulous individuals as controls. The opening position and direction of the mental foramen, and the distance from the mental foramen to the anterior loop were measured with DICOM viewer software in CT images. The opening direction of the mental foramen turned from lateral to superior with the gain of mandibular ridge resorption. Distance from the mental foramen to the anterior loop was decreased significantly with the gain of mandibular ridge resorption. This study revealed that the mental foramen changed position and direction with resorption of the anterior loop, suggesting that understanding the change of the mental foramen with the gain of mandibular ridge resorption provides information for prosthodontic treatment such as implant over denture and complete denture that cannot be obtained by two-dimensional analyses such as panoramic radiography.
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  • Elucidation of enamel cross-striation formation mechanism
    Ai Sasaki-Oikawa, Keishi Otsu, Naoki Fujiwara, Kiyoto Ishizeki, Mitsus ...
    Article type: Article
    2012 Volume 37 Issue 1 Pages 14-23
    Published: May 11, 2012
    Released on J-STAGE: March 06, 2017
    DOIhttps://njjn-jsjc-gov-cn-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.20663/iwateshigakukaishi.37.1_14
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    In enamel rods, periodic bands referred to as 'cross-striations' are observed, and known as incremental lines of circadian rhythm. Though it is considered that the cross-striation is involved in the biological circadian rhythm during the secretion of enamel matrix protein by ameloblasts, the developmental mechanism involved has not been examined in detail. By immunostaining amelogenin in fresh frozen sections of mouse lower incisor, we could observe fluorescent periodic bands in the enamel matrix, which were identical to the pattern of these cross-striations. Accordingly, we focused on the biological rhythm in the section of amelogenin. We examined amelogenin mRNA transcriptional activity in an ameloblast cell line (HAT7) by using real-time luminescence microscopy. The results showed that amelogenin mRNA transcriptional activity exhibited periodic rhythmicity and that Msx2 over-expression led to the disappearance of the periodic change. Further, in the lower incisors of Msx2-deficient mice, the periodic bands were not observed. Taken together, our findings suggest that the formation of cross-striations in the enamel rods was associated with the expression of amelogenin regulated by the transcriptional activity.
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  • Anatomical analyses on the expression of the fluorescence in tdTomato transgenic mice
    Yukinori Kuwajima, Masato Ootuka, Akira Ishizaki, Akira Fujimura
    Article type: Article
    2012 Volume 37 Issue 1 Pages 24-37
    Published: May 11, 2012
    Released on J-STAGE: March 06, 2017
    DOIhttps://njjn-jsjc-gov-cn-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.20663/iwateshigakukaishi.37.1_24
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    The red fluorescent transgenic mouse has given us a promising insight into regenerative medicine. Each organ of this animal has already been investigated by the method of using a fluorescent imaging system, but not by histological methods. First of all, we compared all the organs of the red fluorescent transgenic mouse with previous studies using enhanced green fluorescent protein (EGFP) mice by the IVIS Luminal Imaging. Next the expression levels of each organs mRNA was measured by RT-PCR. Further, the histological sections of the red fluorescent transgenic mice (7 days after-birth) were taken by light microscope. The results of the three methods were compared and the following findings were made ; We found a discrepancy between the fluorescent imaging method which was used in past reports and the expression levels of mRNA and multiple discrepancies between these and the histological observations. Explaining the discrepancies was beyond the scope of this experiment. We thought that two or more methods including the histological examination were reguired by future research and verification. The red fluorescent transgenic mouse was more useful than the EGFP mouse in the fluorescent expression of the hepar, spleen and ren. All of the organs in the red fluorescent transgenic mouse have a strong fluorescent expression. We hope that these red fluorescent transgenic mice are used in the research of regenerative medicine and the metastic route of the tumor stem cell.
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  • Changes of nitric oxide (NO) by various vasodilators in vascular smooth muscle of swine lingual artery
    Daiji Yamada, Kenichi Satoh
    Article type: Article
    2012 Volume 37 Issue 1 Pages 38-52
    Published: May 11, 2012
    Released on J-STAGE: March 06, 2017
    DOIhttps://njjn-jsjc-gov-cn-s-1416.res.gxlib.org.cn:443/rwt/1416/https/MSYXTLUQPJUB/10.20663/iwateshigakukaishi.37.1_38
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    The nitric oxide (NO), which is the main subject of the endothelium-derived relaxing-factor (EDRF), bears an important role in maintaining cardiovascular homeostasis. However, we were not able to look for a report of NO on the vessel in oral area. Then, this research was planned in order to clarify NO action and mechanism on the lingual artery. Change of NO was measured directly using the electrode method by perfusing various vasodepressors (Acetylcholine(ACh), Carbachol, Pilocarpine) after Noradrenaline (NA) to a swine lingual-artery vascular smooth muscle. Changes in isometric contraction and intracellular calcium ion concentration ([Ca^<2+>]_i) were measured simultaneously, and their relation to NO was investigated. The following results were obtained; 1. The direct measurement of NO by an electrode method is useful to measure the exact value of NO with time. 2. In Ach, release of NO decreased so that Ach concentration rose, but the lingual-artery vascular smooth muscle contraction by NA was decreased with elevation of NO. 3. In Carbachol, NO increased in concentration dependent manner and the smooth muscle contraction decreased significantly, but most changes of [Ca^<2+>]_i were not seen in each concentration. 4. In Pilocarpine, NO increased in concentration dependent manner. The contraction by NA showed the trend which decreases in concentration dependent manner. [Ca^<2+>]_i showed an almost comparable reduction in each concentration.
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