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Volume 22 (2011)
- Issue 6 Pages 343-
- Issue 5 Pages 225-
- Issue 4 Pages 143-
- Issue 3 Pages 71-
- Issue 1 Pages 3-
Predecessor
Volume 22, Issue 6
Displaying 1-8 of 8 articles from this issue
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Reviews : ISTH-Kyoto2011
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Nobuyuki TAKAKURA2011 Volume 22 Issue 6 Pages 343-347
Published: December 01, 2011
Released on J-STAGE: December 22, 2011
JOURNAL FREE ACCESSBlood vessels constructed by vasculogenesis are immature. For the maturation of vessel structure, mural cells (MCs), such as pericytes or smooth muscle cells, have to adhere to endothelial cells (ECs). In the maturation process involved in blood vessel formation, the ECs which form the tube, recruit supporting MCs, by releasing PDGF-BB. MCs subsequently adhere to ECs resulting in the formation of a structurally-stable blood vessel. It has been proposed that this cell adhesion between ECs and MCs is induced when angiopoietin-1, produced from MCs, stimulates Tie2, a receptor tyrosine kinase on ECs. During angiogenesis, blood vessels should be able to adjust their caliber, in order to allow them to respond adequately to the changes in demand for oxygen and nutrients made by the organs and tissues. This caliber adjustment is involved in the maturation process during angiogenesis. Apelin, produced from ECs via activation of Tie2 stimulates APJ, a GPCR expressed on ECs induces non-leaky enlarged blood vessels. Besides such molecular signals for blood vessel maturation, recently it has been clarified that phalanx cells among ECs induce maturation of blood vessels.View full abstractDownload PDF (3372K) -
from discovery to prospectsKatsue SUZUKI-INOUE, Osamu INOUE, Yukio OZAKI2011 Volume 22 Issue 6 Pages 348-362
Published: December 01, 2011
Released on J-STAGE: December 22, 2011
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Masakatsu NISHIKAWA, Hiroyoshi HIDAKA2011 Volume 22 Issue 6 Pages 363-367
Published: December 01, 2011
Released on J-STAGE: December 22, 2011
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Koichi KOKAME2011 Volume 22 Issue 6 Pages 368-373
Published: December 01, 2011
Released on J-STAGE: December 22, 2011
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Topics
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Yuko SUZUKI2011 Volume 22 Issue 6 Pages 374-376
Published: December 01, 2011
Released on J-STAGE: December 22, 2011
JOURNAL FREE ACCESSDownload PDF (6678K)
Technical Lecture
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A new approach of immune tolerance induction therapy for hemophilia A inhibitorsHideto MATSUI2011 Volume 22 Issue 6 Pages 377-383
Published: December 01, 2011
Released on J-STAGE: December 22, 2011
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Small talks on my research career
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Taiichiro SEKI2011 Volume 22 Issue 6 Pages 384-388
Published: December 01, 2011
Released on J-STAGE: December 22, 2011
JOURNAL FREE ACCESSDownload PDF (1312K)
Report
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2011 Volume 22 Issue 6 Pages 389-393
Published: December 01, 2011
Released on J-STAGE: December 22, 2011
JOURNAL FREE ACCESSDownload PDF (1228K)
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