Visual information is processed in parallel via the magno (M) and parvo (P) cellular systems. The M system comprises the dorsal pathway (V1 to V5/MT) and is important for motion perception and stereopsis. In contrast, the P system comprises the ventral stream(V1 to V4 of the inferior temporal cortex) and is responsible for fine vision and color/face perception. Here, we demonstrate that multimodality visual evoked potentials are useful for exploring patients with dementia and autistic spectrum disorder(ASD). In mild cognitive impairment(MCI), the functions of the ventral stream was normal. Motion perception was normal in horizontal motion (HO) perception, but radial motion(optic flow : OF) processing related to self-motion perception was abnormal. Similarly, abnormal HO and OF processing was observed in Alzheimer’s disease(AD), suggesting systemicopathy of the dorsal stream in AD and MCI. In Asperger’s syndrome (high-functioning ASD), we found not only impaired threshold face recognition, but also abnormal unconscious face processing for motional faces. In addition, OF cognition was selectively impaired, indicating impairment of the ventraldorsal system. In order to explain this complex pathology in a unified manner, a new model of visual network abnormality has been proposed, namely, the concept of functional connectopathy(connectopathy).
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