The objective of the present study is to assess overall uncertainty in biokinetic and dosimetric models of α, β, αγ, and βγ- emitters. International Standard Organization (ISO) methods on uncertainty assessment have been applied taking into account all biokinetic and dosimetric parameters intervening in the determination of the ingestion dose coefficients of radionuclides. Clear uncertainty budget and well established mathematical formulas were obtained for α-, β-, αγ-, and βγ- emitters from the updated ingestion dose coefficients. This method was applied to 238U, an αγ- emitter, and can be generalized to other radionuclides. By ranging the relative uncertainty on the Absorbed Fractions, Numbers of transformations, Radiation and Tissue weighting factors and wall parameter from 5% to their nominal values in the literature, an overall relative uncertainty ranging from 126 to 176% was brought out. Thus biokinetic and dosimetric models of radionuclides should be improved to make them more realistic, reducing the above uncertainty. Correlations between Specific Absorbed Fractions of each source and corresponding targets will be taken into account very soon within the framework of a specific study using Monte Carlo calculations.
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